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Assay Detail

CHEMBL978463

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity assessed as inhibition of total reactive oxygen species generation in Wistar rat kidney by 2',7'-dichlorofluorescein based fluorescence spectroscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Kidney
Confidence 1 — Organism
Curated By Autocuration

Target

Kidney (CHEMBL613638)
Type TISSUE
Organism Rattus norvegicus

Publication

Antioxidative phenolics from the fresh leaves of Ternstroemia japonica.
Jo Y, Kim M, Shin MH, Chung HY, Jung JH, Im KS.
J Nat Prod (2006) 69 : 1399 -1403
PubMed 17067150 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.33 4.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50 QUERCETIN 3.0 1 4.54
CHEMBL153 TROLOX 1 4.53
CHEMBL446760 TERNSTROSIDE C 1 4.48
CHEMBL465424 TERNSTROSIDE A 1 4.41
CHEMBL469425 TERNSTROSIDE F 1 4.34
CHEMBL1162980 TERNSTROSIDE E 1 4.26
CHEMBL462808 TERNSTROSIDE B 1 4.20
CHEMBL462809 TERNSTROSIDE D 1 4.17
CHEMBL506637 1 4.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50 QUERCETIN IC50 = 29120.0 nM 4.54
CHEMBL153 TROLOX IC50 = 29520.0 nM 4.53
CHEMBL446760 TERNSTROSIDE C IC50 = 33290.0 nM 4.48
CHEMBL465424 TERNSTROSIDE A IC50 = 39260.0 nM 4.41
CHEMBL469425 TERNSTROSIDE F IC50 = 45360.0 nM 4.34
CHEMBL1162980 TERNSTROSIDE E IC50 = 54980.0 nM 4.26
CHEMBL462808 TERNSTROSIDE B IC50 = 62520.0 nM 4.20
CHEMBL462809 TERNSTROSIDE D IC50 = 66870.0 nM 4.17
CHEMBL506637 IC50 = 82210.0 nM 4.08