Assay Detail
Binding
CHEMBL978649
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Inhibition of drug-resistant EGFR-T790 mutant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.62 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285063 | — | — | 1 | 8.92 |
| CHEMBL94061 | — | — | 1 | 8.52 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.58 |
| CHEMBL188762 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285063 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL94061 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL188762 | — | IC50 | = | 360.0 | nM | 6.44 |