Assay Detail
Binding
CHEMBL979029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells by scintillation counting
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.48 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247733 | — | — | 1 | 6.14 |
| CHEMBL450813 | — | — | 1 | 5.95 |
| CHEMBL476954 | — | — | 1 | 5.90 |
| CHEMBL477374 | — | — | 1 | 5.23 |
| CHEMBL469068 | — | — | 1 | 4.99 |
| CHEMBL477580 | — | — | 1 | 4.67 |
| CHEMBL477586 | — | — | 1 | - |
| CHEMBL518580 | — | — | 1 | - |
| CHEMBL477584 | — | — | 1 | - |
| CHEMBL517963 | — | — | 1 | - |
| CHEMBL476116 | — | — | 1 | - |
| CHEMBL513884 | — | — | 1 | - |
| CHEMBL446281 | — | — | 1 | - |
| CHEMBL448900 | — | — | 1 | - |
| CHEMBL469233 | — | — | 1 | - |
| CHEMBL513360 | — | — | 1 | - |
| CHEMBL449145 | — | — | 1 | - |
| CHEMBL469222 | — | — | 1 | - |
| CHEMBL513139 | — | — | 1 | - |
| CHEMBL512472 | — | — | 1 | - |
| CHEMBL466963 | — | — | 1 | - |
| CHEMBL512967 | — | — | 1 | - |
| CHEMBL513313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247733 | — | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL450813 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL476954 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL477374 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL469068 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL477580 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL477586 | — | IC50 | - | — | - | |
| CHEMBL518580 | — | IC50 | - | — | - | |
| CHEMBL477584 | — | IC50 | - | — | - | |
| CHEMBL517963 | — | IC50 | - | — | - | |
| CHEMBL476116 | — | IC50 | - | — | - | |
| CHEMBL513884 | — | IC50 | - | — | - | |
| CHEMBL446281 | — | IC50 | - | — | - | |
| CHEMBL448900 | — | IC50 | - | — | - | |
| CHEMBL469233 | — | IC50 | - | — | - | |
| CHEMBL513360 | — | IC50 | - | — | - | |
| CHEMBL449145 | — | IC50 | - | — | - | |
| CHEMBL469222 | — | IC50 | - | — | - | |
| CHEMBL513139 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL512472 | — | IC50 | - | — | - | |
| CHEMBL466963 | — | IC50 | - | — | - | |
| CHEMBL512967 | — | IC50 | - | — | - | |
| CHEMBL513313 | — | IC50 | - | — | - |