Assay Detail
Binding
CHEMBL979037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG potassium channel
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.51 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476954 | — | — | 1 | 4.61 |
| CHEMBL513139 | — | — | 1 | 4.40 |
| CHEMBL477374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476954 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL513139 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL477374 | — | IC50 | > | 6870.0 | nM | - |