Assay Detail
Binding
CHEMBL979352
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Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.03 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 8.60 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.70 |
| CHEMBL255898 | BARETTIN | — | 1 | 6.47 |
| CHEMBL511609 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1065 | METHYSERGIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL39 | SEROTONIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL255898 | BARETTIN | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL511609 | — | Ki | = | 4630.0 | nM | 5.33 |