Assay Detail
Functional
CHEMBL979360
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Inhibition of ICAM1 induction in human A549 cells pretreated for 1 hr in presence of TNFalpha for 6 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive guaianolides from siyekucai (Ixeris chinensis).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.81 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518687 | — | — | 1 | 4.94 |
| CHEMBL463601 | — | — | 1 | 4.78 |
| CHEMBL448636 | — | — | 1 | 4.70 |
| CHEMBL516875 | — | — | 1 | - |
| CHEMBL507663 | CHINENSIOLIDE E | — | 1 | - |
| CHEMBL455771 | IXEROCHINOSIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518687 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL463601 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL448636 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL516875 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL507663 | CHINENSIOLIDE E | IC50 | > | 100000.0 | nM | - |
| CHEMBL455771 | IXEROCHINOSIDE | IC50 | > | 100000.0 | nM | - |