Assay Detail
Functional
CHEMBL979366
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Cytotoxicity against human VA13 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WI-38 VA13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive guaianolides from siyekucai (Ixeris chinensis).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.86 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.30 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.40 |
| CHEMBL507663 | CHINENSIOLIDE E | — | 1 | 6.14 |
| CHEMBL448636 | — | — | 1 | 5.07 |
| CHEMBL463602 | — | — | 1 | 4.66 |
| CHEMBL463601 | — | — | 1 | 4.57 |
| CHEMBL516875 | — | — | 1 | - |
| CHEMBL465422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL507663 | CHINENSIOLIDE E | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL448636 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL463602 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL463601 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL516875 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL465422 | — | IC50 | = | 160000.0 | nM | - |