Assay Detail
Functional
CHEMBL979570
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Thai after 24 hrs by semiautomated micro dilution assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial activity of new analogues of amodiaquine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.83 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147587 | ISOQUINE | — | 1 | 8.37 |
| CHEMBL1630 | — | — | 1 | 8.34 |
| CHEMBL138623 | — | — | 1 | 7.88 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.84 |
| CHEMBL509425 | — | — | 1 | 7.82 |
| CHEMBL451753 | — | — | 1 | 7.81 |
| CHEMBL507466 | — | — | 1 | 7.79 |
| CHEMBL454078 | — | — | 1 | 7.60 |
| CHEMBL453824 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147587 | ISOQUINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1630 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL138623 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL509425 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL451753 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL507466 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL454078 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL453824 | — | IC50 | = | 103.5 | nM | 6.99 |