Assay Detail
Functional
CHEMBL979571
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1R after 24 hrs by semiautomated micro dilution assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial activity of new analogues of amodiaquine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.63 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630 | — | — | 1 | 8.32 |
| CHEMBL147587 | ISOQUINE | — | 1 | 8.27 |
| CHEMBL138623 | — | — | 1 | 7.80 |
| CHEMBL507466 | — | — | 1 | 7.74 |
| CHEMBL451753 | — | — | 1 | 7.72 |
| CHEMBL509425 | — | — | 1 | 7.49 |
| CHEMBL454078 | — | — | 1 | 7.45 |
| CHEMBL453824 | — | — | 1 | 7.02 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL147587 | ISOQUINE | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL138623 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL507466 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL451753 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL509425 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL454078 | — | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL453824 | — | IC50 | = | 95.2 | nM | 7.02 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 126.0 | nM | 6.90 |