Assay Detail
Functional
CHEMBL979829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 infected human erythrocytes by SYBR green assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.61 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.97 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 6.43 |
| CHEMBL491753 | — | — | 1 | 5.80 |
| CHEMBL491890 | — | — | 1 | 5.75 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.70 |
| CHEMBL491464 | — | — | 1 | 5.58 |
| CHEMBL491889 | — | — | 1 | 5.57 |
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | 5.41 |
| CHEMBL491754 | — | — | 1 | 5.24 |
| CHEMBL444412 | — | — | 1 | 5.12 |
| CHEMBL523652 | — | — | 1 | 4.99 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 106.4 | nM | 6.97 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL491753 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL491890 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL491464 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL491889 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL505 | CHLORPHENIRAMINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL491754 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL444412 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL523652 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 16600.0 | nM | 4.78 |