Assay Detail
Functional
CHEMBL979831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity after 72 hrs against chloroquine-resistant transporter 106/1'76N mutant Plasmodium falciparum infected human erythrocytes by SYBR green assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.57 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.32 |
| CHEMBL491889 | — | — | 1 | 6.22 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL491889 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 653.0 | nM | 6.18 |