Assay Detail
Functional
CHEMBL979832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes by SYBR green assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.68 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.83 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 7.74 |
| CHEMBL491464 | — | — | 1 | 5.89 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.89 |
| CHEMBL491890 | — | — | 1 | 5.58 |
| CHEMBL491889 | — | — | 1 | 5.50 |
| CHEMBL491754 | — | — | 1 | 5.43 |
| CHEMBL523652 | — | — | 1 | 5.12 |
| CHEMBL491753 | — | — | 1 | 5.09 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 4.94 |
| CHEMBL444412 | — | — | 1 | 4.93 |
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL491464 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL491890 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL491889 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL491754 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL523652 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL491753 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL444412 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL505 | CHLORPHENIRAMINE | IC50 | = | 61200.0 | nM | 4.21 |