Assay Detail
Binding
CHEMBL979907
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Binding affinity to RasGRP3
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.29 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511820 | — | — | 1 | 8.74 |
| CHEMBL519398 | — | — | 1 | 8.65 |
| CHEMBL471153 | — | — | 1 | 8.64 |
| CHEMBL488675 | — | — | 1 | 8.42 |
| CHEMBL472002 | — | — | 1 | 8.41 |
| CHEMBL452307 | — | — | 1 | 8.33 |
| CHEMBL472001 | — | — | 1 | 8.28 |
| CHEMBL472171 | — | — | 1 | 8.10 |
| CHEMBL471317 | — | — | 1 | 8.03 |
| CHEMBL472174 | — | — | 1 | 7.84 |
| CHEMBL513069 | — | — | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511820 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL519398 | — | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL471153 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL488675 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL472002 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL452307 | — | Ki | = | 4.68 | nM | 8.33 |
| CHEMBL472001 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL472171 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL471317 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL472174 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL513069 | — | Ki | = | 16.4 | nM | 7.79 |