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Assay Detail

CHEMBL979954

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum THAI/Thailand as [3H]hypoxanthine uptake after 24 hrs by semi-automated micro dilution
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.
Delarue-Cochin S, Grellier P, Maes L, Mouray E, Sergheraert C, Melnyk P.
Eur J Med Chem (2008) 43 : 2045 -2055
PubMed 18226428 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.63 8.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1630 1 8.34
CHEMBL76 CHLOROQUINE 4.0 1 7.84
CHEMBL505649 1 7.71
CHEMBL523764 1 7.42
CHEMBL447493 1 7.41
CHEMBL98566 1 7.05
CHEMBL475749 1 -
CHEMBL471539 1 -
CHEMBL449309 1 -
CHEMBL471540 1 -
CHEMBL474737 1 -
CHEMBL475338 1 -
CHEMBL475535 1 -
CHEMBL514347 1 -
CHEMBL472701 1 -
CHEMBL472404 1 -
CHEMBL490276 1 -
CHEMBL490277 1 -
CHEMBL505883 1 -
CHEMBL508376 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1630 IC50 = 4.6 nM 8.34
CHEMBL76 CHLOROQUINE IC50 = 14.3 nM 7.84
CHEMBL505649 IC50 = 19.4 nM 7.71
CHEMBL523764 IC50 = 38.4 nM 7.42
CHEMBL447493 IC50 = 38.6 nM 7.41
CHEMBL98566 IC50 = 89.6 nM 7.05
CHEMBL475749 IC50 - -
CHEMBL471539 IC50 - -
CHEMBL449309 IC50 - -
CHEMBL471540 IC50 - -
CHEMBL474737 IC50 - -
CHEMBL475338 IC50 - -
CHEMBL475535 IC50 - -
CHEMBL514347 IC50 - -
CHEMBL472701 IC50 - -
CHEMBL472404 IC50 - -
CHEMBL490276 IC50 - -
CHEMBL490277 IC50 - -
CHEMBL505883 IC50 - -
CHEMBL508376 IC50 - -