Assay Detail
Binding
CHEMBL980391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H2]nTZD4 from human PPARalpha by scintillation proximity assay
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.09 | 6.48 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478725 | — | — | 1 | 6.48 |
| CHEMBL477298 | — | — | 1 | 6.28 |
| CHEMBL104850 | — | — | 1 | 6.16 |
| CHEMBL477095 | — | — | 1 | 6.04 |
| CHEMBL478334 | — | — | 1 | 5.84 |
| CHEMBL477323 | — | — | 1 | 5.72 |
| CHEMBL515972 | — | — | 1 | - |
| CHEMBL477318 | — | — | 1 | - |
| CHEMBL478335 | — | — | 1 | - |
| CHEMBL515181 | — | — | 1 | - |
| CHEMBL477690 | — | — | 1 | - |
| CHEMBL516129 | — | — | 1 | - |
| CHEMBL513904 | — | — | 1 | - |
| CHEMBL514696 | — | — | 1 | - |
| CHEMBL479002 | — | — | 1 | - |
| CHEMBL479001 | — | — | 1 | - |
| CHEMBL477941 | — | — | 1 | - |
| CHEMBL477940 | — | — | 1 | - |
| CHEMBL476897 | — | — | 1 | - |
| CHEMBL476896 | — | — | 1 | - |
| CHEMBL478726 | — | — | 1 | - |
| CHEMBL478563 | — | — | 1 | - |
| CHEMBL477094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478725 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL477298 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL104850 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL477095 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL478334 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL477323 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL515972 | — | IC50 | - | — | - | |
| CHEMBL477318 | — | IC50 | > | 3300.0 | nM | - |
| CHEMBL478335 | — | IC50 | - | — | - | |
| CHEMBL515181 | — | IC50 | - | — | - | |
| CHEMBL477690 | — | IC50 | - | — | - | |
| CHEMBL516129 | — | IC50 | - | — | - | |
| CHEMBL513904 | — | IC50 | - | — | - | |
| CHEMBL514696 | — | IC50 | - | — | - | |
| CHEMBL479002 | — | IC50 | > | 3300.0 | nM | - |
| CHEMBL479001 | — | IC50 | - | — | - | |
| CHEMBL477941 | — | IC50 | - | — | - | |
| CHEMBL477940 | — | IC50 | - | — | - | |
| CHEMBL476897 | — | IC50 | - | — | - | |
| CHEMBL476896 | — | IC50 | - | — | - | |
| CHEMBL478726 | — | IC50 | - | — | - | |
| CHEMBL478563 | — | Activity | - | — | - | |
| CHEMBL477094 | — | IC50 | - | — | - |