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Assay Detail

CHEMBL980502

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MRC5 cells by alamar-blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei.
Mbwambo ZH, Kapingu MC, Moshi MJ, Machumi F, Apers S, Cos P, Ferreira D, Marais JP, Vanden Berghe D, Maes L, Vlietinck A, Pieters L.
J Nat Prod (2006) 69 : 369 -372
PubMed 16562837 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 4.70 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL454538 GARCILIVIN A 1 5.70
CHEMBL500482 1 4.42
CHEMBL463023 VOLKENSIFLAVONE 1 4.40
CHEMBL499445 GARCIVILIN C 1 4.28
CHEMBL479289 1 -
CHEMBL188061 1 -
CHEMBL482023 1 -
CHEMBL1215433 MORELLOFLAVONE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL454538 GARCILIVIN A IC50 = 2000.0 nM 5.70
CHEMBL500482 IC50 = 38000.0 nM 4.42
CHEMBL463023 VOLKENSIFLAVONE IC50 = 40000.0 nM 4.40
CHEMBL499445 GARCIVILIN C IC50 = 52300.0 nM 4.28
CHEMBL479289 IC50 > 64000.0 nM -
CHEMBL188061 IC50 > 32000.0 nM -
CHEMBL482023 IC50 > 64000.0 nM -
CHEMBL1215433 MORELLOFLAVONE IC50 > 64000.0 nM -