Assay Detail
Functional
CHEMBL980652
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Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS binding
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.02 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514302 | — | — | 1 | 9.28 |
| CHEMBL473238 | — | — | 1 | 8.96 |
| CHEMBL474418 | — | — | 1 | 8.66 |
| CHEMBL475253 | — | — | 1 | 8.57 |
| CHEMBL473156 | — | — | 1 | 8.54 |
| CHEMBL515917 | — | — | 1 | 8.14 |
| CHEMBL470511 | — | — | 1 | 7.99 |
| CHEMBL473562 | — | — | 1 | 7.43 |
| CHEMBL514170 | — | — | 1 | 7.43 |
| CHEMBL473563 | — | — | 1 | 7.36 |
| CHEMBL475405 | — | — | 1 | 7.25 |
| CHEMBL515603 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514302 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL473238 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL474418 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL475253 | — | EC50 | = | 2.67 | nM | 8.57 |
| CHEMBL473156 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL515917 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL470511 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL473562 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL514170 | — | EC50 | = | 37.2 | nM | 7.43 |
| CHEMBL473563 | — | EC50 | = | 44.1 | nM | 7.36 |
| CHEMBL475405 | — | EC50 | = | 56.1 | nM | 7.25 |
| CHEMBL515603 | — | EC50 | = | 247.0 | nM | 6.61 |