Assay Detail
Functional
CHEMBL980654
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Inverse agonist activity at cannabinoid CB1 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.69 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220360 | TARANABANT | 3.0 | 1 | 9.52 |
| CHEMBL246723 | — | — | 1 | 8.43 |
| CHEMBL204232 | NAPHTHYRIDINONE | — | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220360 | TARANABANT | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL246723 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL204232 | NAPHTHYRIDINONE | IC50 | = | 7.5 | nM | 8.12 |