Assay Detail
Binding
CHEMBL980737
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Inhibition of 20-alpha HSD
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Aldo-keto reductase family 1 member C1 (CHEMBL5905) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.67 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449129 | — | — | 1 | 8.22 |
| CHEMBL521800 | — | — | 1 | 7.48 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449129 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL521800 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 48.0 | nM | 7.32 |