Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL980782

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]2AD-5075 from GST-tagged human PPARgamma receptor expressed in Escherichia coli BL21
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor gamma (CHEMBL235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Highly functionalized 7-azaindoles as selective PPAR gamma modulators.
Debenham SD, Chan A, Lau FW, Liu W, Wood HB, Lemme K, Colwell L, Habulihaz B, Akiyama TE, Einstein M, Doebber TW, Sharma N, Wang CF, Wu M, Berger JP, Meinke PT.
Bioorg Med Chem Lett (2008) 18 : 4798 -4801
PubMed 18701276 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.96 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL460072 1 9.00
CHEMBL452051 1 9.00
CHEMBL460073 1 8.70
CHEMBL462378 1 8.70
CHEMBL461944 1 8.52
CHEMBL518499 1 8.52
CHEMBL509236 1 8.40
CHEMBL455127 1 8.30
CHEMBL507477 1 8.00
CHEMBL461378 1 7.82
CHEMBL510180 1 7.80
CHEMBL517436 1 7.66
CHEMBL461379 1 7.64
CHEMBL452054 1 7.60
CHEMBL509369 1 7.27
CHEMBL455126 1 7.18
CHEMBL455130 1 6.97
CHEMBL452299 1 6.14
CHEMBL459466 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL460072 IC50 = 1.0 nM 9.00
CHEMBL452051 IC50 = 1.0 nM 9.00
CHEMBL460073 IC50 = 2.0 nM 8.70
CHEMBL462378 IC50 = 2.0 nM 8.70
CHEMBL461944 IC50 = 3.0 nM 8.52
CHEMBL518499 IC50 = 3.0 nM 8.52
CHEMBL509236 IC50 = 4.0 nM 8.40
CHEMBL455127 IC50 = 5.0 nM 8.30
CHEMBL507477 IC50 = 10.0 nM 8.00
CHEMBL461378 IC50 = 15.0 nM 7.82
CHEMBL510180 IC50 = 16.0 nM 7.80
CHEMBL517436 IC50 = 22.0 nM 7.66
CHEMBL461379 IC50 = 23.0 nM 7.64
CHEMBL452054 IC50 = 25.0 nM 7.60
CHEMBL509369 IC50 = 54.0 nM 7.27
CHEMBL455126 IC50 = 66.0 nM 7.18
CHEMBL455130 IC50 = 106.0 nM 6.97
CHEMBL452299 IC50 = 726.0 nM 6.14
CHEMBL459466 IC50 < 1.0 nM -