Assay Detail
Binding
CHEMBL981107
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Inhibition of DPP4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The many roles for fluorine in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.10 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.75 |
| CHEMBL216186 | — | — | 1 | 7.57 |
| CHEMBL233685 | — | — | 1 | 7.43 |
| CHEMBL479370 | — | — | 1 | 7.17 |
| CHEMBL517072 | — | — | 1 | 7.15 |
| CHEMBL394834 | — | — | 1 | 7.06 |
| CHEMBL242813 | — | — | 1 | 6.89 |
| CHEMBL394833 | — | — | 1 | 6.82 |
| CHEMBL243872 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL216186 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL233685 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL479370 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL517072 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL394834 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL242813 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL394833 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL243872 | — | IC50 | = | 805.0 | nM | 6.09 |