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Assay Detail

CHEMBL981122

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL218)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel sterically hindered cannabinoid CB1 receptor ligands.
Urbani P, Cascio MG, Ramunno A, Bisogno T, Saturnino C, Di Marzo V.
Bioorg Med Chem (2008) 16 : 7510 -7515
PubMed 18579386 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.39 8.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL285932 1 8.64
CHEMBL111 RIMONABANT 4.0 1 8.10
CHEMBL476529 1 7.24
CHEMBL475910 1 6.66
CHEMBL476317 1 6.55
CHEMBL479094 1 6.25
CHEMBL476576 1 6.25
CHEMBL518595 1 6.25
CHEMBL478210 1 6.25
CHEMBL475909 1 6.25
CHEMBL502133 1 6.25
CHEMBL478624 1 6.25
CHEMBL517815 1 6.10
CHEMBL479095 1 6.05
CHEMBL478856 1 5.80
CHEMBL478643 1 5.72
CHEMBL476545 1 5.66
CHEMBL478625 1 5.66
CHEMBL476336 1 5.47
CHEMBL381689 SR-144528 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL285932 Ki = 2.3 nM 8.64
CHEMBL111 RIMONABANT Ki = 8.0 nM 8.10
CHEMBL476529 Ki = 58.0 nM 7.24
CHEMBL475910 Ki = 220.0 nM 6.66
CHEMBL476317 Ki = 280.0 nM 6.55
CHEMBL479094 Ki = 560.0 nM 6.25
CHEMBL476576 Ki = 560.0 nM 6.25
CHEMBL518595 Ki = 560.0 nM 6.25
CHEMBL478210 Ki = 560.0 nM 6.25
CHEMBL475909 Ki = 560.0 nM 6.25
CHEMBL502133 Ki = 560.0 nM 6.25
CHEMBL478624 Ki = 560.0 nM 6.25
CHEMBL517815 Ki = 800.0 nM 6.10
CHEMBL479095 Ki = 900.0 nM 6.05
CHEMBL478856 Ki = 1600.0 nM 5.80
CHEMBL478643 Ki = 1900.0 nM 5.72
CHEMBL476545 Ki = 2200.0 nM 5.66
CHEMBL478625 Ki = 2200.0 nM 5.66
CHEMBL476336 Ki = 3400.0 nM 5.47
CHEMBL381689 SR-144528 Ki > 5600.0 nM -