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Assay Detail

CHEMBL981154

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Functional
Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16
Confidence 1 — Organism
Curated By Autocuration

Target

B16 (CHEMBL381)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
Ty N, Dupeyre G, Chabot GG, Seguin J, Tillequin F, Scherman D, Michel S, Cachet X.
Bioorg Med Chem (2008) 16 : 7494 -7503
PubMed 18583138 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.17 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67 COMBRETASTATIN A4 -1.0 1 8.52
CHEMBL364123 1 7.89
CHEMBL107 COLCHICINE 4.0 1 7.51
CHEMBL475923 1 6.77
CHEMBL478857 1 6.62
CHEMBL514614 1 5.50
CHEMBL473045 1 5.48
CHEMBL518439 1 5.29
CHEMBL476334 1 4.91
CHEMBL479070 1 4.86
CHEMBL515468 1 4.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67 COMBRETASTATIN A4 IC50 = 3.0 nM 8.52
CHEMBL364123 IC50 = 13.0 nM 7.89
CHEMBL107 COLCHICINE IC50 = 31.0 nM 7.51
CHEMBL475923 IC50 = 170.0 nM 6.77
CHEMBL478857 IC50 = 240.0 nM 6.62
CHEMBL514614 IC50 = 3140.0 nM 5.50
CHEMBL473045 IC50 = 3290.0 nM 5.48
CHEMBL518439 IC50 = 5070.0 nM 5.29
CHEMBL476334 IC50 = 12180.0 nM 4.91
CHEMBL479070 IC50 = 13670.0 nM 4.86
CHEMBL515468 IC50 = 32420.0 nM 4.49