Assay Detail
Binding
CHEMBL981176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Syk
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.72 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475575 | — | — | 1 | 8.40 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.05 |
| CHEMBL475609 | — | — | 1 | 8.05 |
| CHEMBL474582 | — | — | 1 | 8.05 |
| CHEMBL471901 | — | — | 1 | 7.39 |
| CHEMBL472840 | — | — | 1 | 7.30 |
| CHEMBL478642 | — | — | 1 | 7.08 |
| CHEMBL475882 | — | — | 1 | 6.92 |
| CHEMBL476741 | — | — | 1 | 6.82 |
| CHEMBL476537 | — | — | 1 | 5.21 |
| CHEMBL477165 | — | — | 1 | 5.11 |
| CHEMBL513915 | — | — | 1 | 4.82 |
| CHEMBL514365 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475575 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL475609 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL474582 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL471901 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL472840 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL478642 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL475882 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL476741 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL476537 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL477165 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL513915 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL514365 | — | IC50 | = | 79100.0 | nM | 4.10 |