Assay Detail
Binding
CHEMBL981177
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Inhibition of human ZAP70
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.90 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.28 |
| CHEMBL472840 | — | — | 1 | 7.01 |
| CHEMBL478642 | — | — | 1 | 6.96 |
| CHEMBL475882 | — | — | 1 | 6.92 |
| CHEMBL475609 | — | — | 1 | 6.92 |
| CHEMBL475575 | — | — | 1 | 6.48 |
| CHEMBL476741 | — | — | 1 | 5.96 |
| CHEMBL476537 | — | — | 1 | 5.19 |
| CHEMBL474582 | — | — | 1 | 5.08 |
| CHEMBL514365 | — | — | 1 | 5.05 |
| CHEMBL471901 | — | — | 1 | 4.95 |
| CHEMBL513915 | — | — | 1 | 4.58 |
| CHEMBL477165 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL472840 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL478642 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL475882 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL475609 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL475575 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL476741 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL476537 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL474582 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL514365 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL471901 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL513915 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL477165 | — | IC50 | = | 50000.0 | nM | 4.30 |