Assay Detail
Functional
CHEMBL981178
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Suppression of IL2 production in human PBMC after 24 hrs by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.80 |
| CHEMBL475609 | — | — | 1 | 7.34 |
| CHEMBL475575 | — | — | 1 | 7.12 |
| CHEMBL478642 | — | — | 1 | 6.68 |
| CHEMBL472840 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL475609 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL475575 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL478642 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL472840 | — | IC50 | = | 1760.0 | nM | 5.75 |