Assay Detail
Functional
CHEMBL981263
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Inhibition of glucose production in rat primary hepatocytes treated for 15 to 30 mins prior to gluconeogenic substrate dihydroxyacetone addition
19
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 4.68 | 5.52 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484162 | — | — | 1 | 5.52 |
| CHEMBL519503 | — | — | 2 | 5.30 |
| CHEMBL484332 | — | — | 1 | 5.12 |
| CHEMBL483354 | — | — | 1 | 5.07 |
| CHEMBL482734 | — | — | 1 | 4.75 |
| CHEMBL519477 | — | — | 1 | 4.62 |
| CHEMBL521795 | — | — | 1 | 4.60 |
| CHEMBL520490 | — | — | 1 | 4.30 |
| CHEMBL447556 | — | — | 1 | 4.12 |
| CHEMBL514660 | — | — | 1 | 4.05 |
| CHEMBL482735 | — | — | 2 | 4.05 |
| CHEMBL507312 | — | — | 1 | - |
| CHEMBL507311 | — | — | 1 | - |
| CHEMBL520157 | — | — | 1 | - |
| CHEMBL489054 | — | — | 1 | - |
| CHEMBL508774 | — | — | 1 | - |
| CHEMBL490065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484162 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL519503 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL484332 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL483354 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL482734 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL519477 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL521795 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL520490 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL447556 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL482735 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL514660 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL489054 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL508774 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL520157 | — | EC50 | = | 250000.0 | nM | - |
| CHEMBL490065 | — | EC50 | - | — | - | |
| CHEMBL519503 | — | Activity | - | — | - | |
| CHEMBL507311 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL482735 | — | Activity | - | — | - | |
| CHEMBL507312 | — | EC50 | > | 25000.0 | nM | - |