Assay Detail
Functional
CHEMBL981345
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Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A mammalian cell agar-diffusion assay for the detection of toxic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.97 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.40 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.15 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.96 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.75 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.48 |
| CHEMBL1237054 | PLICAMYCIN | 4.0 | 1 | 7.48 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.43 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.18 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.00 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.88 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 6.65 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.25 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.16 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 5.91 |
| CHEMBL1489 | AZACITIDINE | 4.0 | 1 | 5.42 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.36 |
| CHEMBL2021450 | CRASSIN ACETATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL61 | PODOFILOX | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL107 | COLCHICINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL50588 | EMETINE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1237054 | PLICAMYCIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL803 | CYTARABINE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL43 | AMSACRINE | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1489 | AZACITIDINE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2021450 | CRASSIN ACETATE | IC50 | = | 0.26 | ug.mL-1 | - |