Assay Detail
Binding
CHEMBL981422
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Inhibition of Src
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and development of aurora kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.50 | 7.09 |
| IC50 | 1 | 7.70 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482968 | ENMD-2076 | 2.0 | 1 | 7.70 |
| CHEMBL359482 | — | — | 1 | 7.09 |
| CHEMBL484950 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482968 | ENMD-2076 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL359482 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL484950 | — | Ki | = | 1258.0 | nM | 5.90 |