Assay Detail
Functional
CHEMBL981463
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Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: improvements of affinity and selectivity for D3 versus D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.62 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484598 | — | — | 1 | 8.85 |
| CHEMBL484599 | — | — | 1 | 8.64 |
| CHEMBL485128 | — | — | 1 | 8.64 |
| CHEMBL484732 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484598 | — | EC50 | = | 1.413 | nM | 8.85 |
| CHEMBL484599 | — | EC50 | = | 2.291 | nM | 8.64 |
| CHEMBL485128 | — | EC50 | = | 2.291 | nM | 8.64 |
| CHEMBL484732 | — | EC50 | = | 4.677 | nM | 8.33 |