Assay Detail
Binding
CHEMBL981820
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Displacement of [3H]spiperone from human wild type D3 receptor expressed in human HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.00 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484358 | — | — | 1 | 9.11 |
| CHEMBL484202 | — | — | 1 | 8.60 |
| CHEMBL285755 | — | — | 1 | 8.44 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.14 |
| CHEMBL162762 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484358 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL484202 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL285755 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL59 | DOPAMINE | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL162762 | — | Ki | = | 190.0 | nM | 6.72 |