Assay Detail
Binding
CHEMBL982080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from adrenergic receptor alpha1 in CRL:CD(SD)BR-COBS rat brain cortex
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.95 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477765 | — | — | 1 | 7.78 |
| CHEMBL479231 | — | — | 1 | 7.70 |
| CHEMBL476104 | — | — | 1 | 7.67 |
| CHEMBL515334 | — | — | 1 | 7.66 |
| CHEMBL477199 | — | — | 1 | 7.59 |
| CHEMBL477200 | — | — | 1 | 7.48 |
| CHEMBL477766 | — | — | 1 | 7.34 |
| CHEMBL478394 | — | — | 1 | 7.33 |
| CHEMBL476722 | — | — | 1 | 7.28 |
| CHEMBL514074 | — | — | 1 | 7.11 |
| CHEMBL476105 | — | — | 1 | 7.11 |
| CHEMBL478413 | — | — | 1 | 7.11 |
| CHEMBL517962 | — | — | 1 | 7.01 |
| CHEMBL478412 | — | — | 1 | 6.90 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 6.70 |
| CHEMBL444988 | — | — | 1 | 6.68 |
| CHEMBL477397 | — | — | 1 | 6.62 |
| CHEMBL478411 | — | — | 1 | 6.60 |
| CHEMBL476363 | — | — | 1 | 6.56 |
| CHEMBL479026 | — | — | 1 | 6.48 |
| CHEMBL514855 | — | — | 1 | 6.34 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.22 |
| CHEMBL479027 | — | — | 1 | 5.78 |
| CHEMBL477828 | — | — | 1 | 5.72 |
| CHEMBL477827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477765 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL479231 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL476104 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL515334 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL477199 | — | Ki | = | 25.9 | nM | 7.59 |
| CHEMBL477200 | — | Ki | = | 33.2 | nM | 7.48 |
| CHEMBL477766 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL478394 | — | Ki | = | 46.7 | nM | 7.33 |
| CHEMBL476722 | — | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL514074 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL476105 | — | Ki | = | 77.4 | nM | 7.11 |
| CHEMBL478413 | — | Ki | = | 77.7 | nM | 7.11 |
| CHEMBL517962 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL478412 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL444988 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL477397 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL478411 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL476363 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL479026 | — | Ki | = | 328.0 | nM | 6.48 |
| CHEMBL514855 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL49 | BUSPIRONE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL479027 | — | Ki | = | 1651.0 | nM | 5.78 |
| CHEMBL477828 | — | Ki | = | 1915.0 | nM | 5.72 |
| CHEMBL477827 | — | Ki | > | 10000.0 | nM | - |