Assay Detail
Binding
CHEMBL982103
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Displacement of [3H]SCH23390 from human cloned dopamine D2L receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine/serotonin receptor ligands. Part 17: a cross-target SAR approach: affinities of azecine-styled ligands for 5-HT(2A) versus D1 and D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.42 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203637 | — | — | 1 | 8.45 |
| CHEMBL380330 | — | — | 1 | 7.89 |
| CHEMBL216258 | — | — | 1 | 7.87 |
| CHEMBL201170 | — | — | 1 | 7.76 |
| CHEMBL389357 | — | — | 1 | 7.61 |
| CHEMBL441618 | — | — | 1 | 7.38 |
| CHEMBL231070 | — | — | 1 | 7.38 |
| CHEMBL245570 | — | — | 1 | 7.36 |
| CHEMBL201525 | — | — | 1 | 7.23 |
| CHEMBL508399 | — | — | 1 | 7.11 |
| CHEMBL276778 | — | — | 1 | 7.06 |
| CHEMBL216439 | — | — | 1 | 6.94 |
| CHEMBL459871 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203637 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL380330 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL216258 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL201170 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL389357 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL441618 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL231070 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL245570 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL201525 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL508399 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL276778 | — | Ki | = | 86.7 | nM | 7.06 |
| CHEMBL216439 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL459871 | — | Ki | = | 389.05 | nM | 6.41 |