Assay Detail
Binding
CHEMBL982334
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Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 24 hrs by SEAP reporter assay
9
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
ent-Kaurane diterpenoids from croton tonkinensis inhibit LPS-induced NF-kappaB activation and NO production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.63 | 7.16 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466571 | — | — | 2 | 7.16 |
| CHEMBL254180 | — | — | 2 | 7.00 |
| CHEMBL399157 | — | — | 2 | 6.96 |
| CHEMBL252112 | — | — | 2 | 6.38 |
| CHEMBL4298697 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466571 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL254180 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL399157 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL252112 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4298697 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL399157 | — | Activity | - | — | - | |
| CHEMBL254180 | — | Activity | - | — | - | |
| CHEMBL252112 | — | Activity | - | — | - | |
| CHEMBL466571 | — | Activity | - | — | - |