Assay Detail
Binding
CHEMBL982355
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Inhibition of cPLA2 in human platelets assessed as arachidonic acid release
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.39 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484413 | — | — | 1 | 8.30 |
| CHEMBL30108 | — | — | 1 | 7.96 |
| CHEMBL484954 | — | — | 1 | 7.80 |
| CHEMBL484953 | — | — | 1 | 7.58 |
| CHEMBL482775 | — | — | 1 | 7.58 |
| CHEMBL205892 | — | — | 1 | 7.46 |
| CHEMBL520836 | — | — | 1 | 7.07 |
| CHEMBL482959 | — | — | 1 | 6.82 |
| CHEMBL205941 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484413 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL30108 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL484954 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL484953 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL482775 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL205892 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL520836 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL482959 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL205941 | — | IC50 | = | 1100.0 | nM | 5.96 |