Assay Detail
Binding
CHEMBL982653
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Inhibition of CRAC channel-mediated calcium influx in human Jurkat cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.48 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459002 | — | — | 1 | 7.11 |
| CHEMBL484354 | — | — | 1 | 7.09 |
| CHEMBL485208 | — | — | 1 | 7.04 |
| CHEMBL456851 | — | — | 1 | 6.96 |
| CHEMBL445490 | — | — | 1 | 6.92 |
| CHEMBL262766 | — | — | 1 | 6.82 |
| CHEMBL456852 | — | — | 1 | 6.82 |
| CHEMBL483198 | — | — | 1 | 6.80 |
| CHEMBL521021 | — | — | 1 | 6.68 |
| CHEMBL456853 | — | — | 1 | 6.66 |
| CHEMBL520993 | — | — | 1 | 6.66 |
| CHEMBL519699 | — | — | 1 | 6.64 |
| CHEMBL431431 | — | — | 1 | 6.62 |
| CHEMBL485590 | — | — | 1 | 6.62 |
| CHEMBL521340 | — | — | 1 | 6.60 |
| CHEMBL514728 | — | — | 1 | 6.57 |
| CHEMBL485396 | — | — | 1 | 6.54 |
| CHEMBL485411 | — | — | 1 | 6.54 |
| CHEMBL504268 | — | — | 1 | 6.40 |
| CHEMBL485405 | — | — | 1 | 6.37 |
| CHEMBL484365 | — | — | 1 | 6.34 |
| CHEMBL484185 | — | — | 1 | 6.14 |
| CHEMBL485241 | — | — | 1 | 6.11 |
| CHEMBL484364 | — | — | 1 | 6.02 |
| CHEMBL458749 | — | — | 1 | 5.80 |
| CHEMBL485596 | — | — | 1 | 5.48 |
| CHEMBL484363 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459002 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL484354 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL485208 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL456851 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL445490 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL262766 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL456852 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL483198 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL521021 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL456853 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL520993 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL519699 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL431431 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL485590 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL521340 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL514728 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL485396 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL485411 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL504268 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL485405 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL484365 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL484185 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL485241 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL484364 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL458749 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL485596 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL484363 | — | IC50 | = | 22000.0 | nM | 4.66 |