Assay Detail
Binding
CHEMBL982655
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Inhibition of VOC channel-mediated calcium influx in mouse PC12-h5 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | PC-12 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.40 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485405 | — | — | 1 | 5.70 |
| CHEMBL485241 | — | — | 1 | 5.62 |
| CHEMBL484185 | — | — | 1 | 5.60 |
| CHEMBL485208 | — | — | 1 | 5.58 |
| CHEMBL484354 | — | — | 1 | 5.54 |
| CHEMBL445490 | — | — | 1 | 5.54 |
| CHEMBL521021 | — | — | 1 | 5.51 |
| CHEMBL504268 | — | — | 1 | 5.46 |
| CHEMBL485590 | — | — | 1 | 5.35 |
| CHEMBL262766 | — | — | 1 | 5.33 |
| CHEMBL519699 | — | — | 1 | 5.32 |
| CHEMBL483198 | — | — | 1 | 5.29 |
| CHEMBL485396 | — | — | 1 | 5.20 |
| CHEMBL431431 | — | — | 1 | 5.00 |
| CHEMBL484364 | — | — | 1 | 5.00 |
| CHEMBL484353 | — | — | 1 | - |
| CHEMBL521319 | — | — | 1 | - |
| CHEMBL520022 | — | — | 1 | - |
| CHEMBL485596 | — | — | 1 | - |
| CHEMBL458749 | — | — | 1 | - |
| CHEMBL485226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485405 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL485241 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL484185 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL485208 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL484354 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL445490 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL521021 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL504268 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL485590 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL262766 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL519699 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL483198 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL485396 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL431431 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL484364 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL484353 | — | IC50 | - | — | - | |
| CHEMBL521319 | — | IC50 | - | — | - | |
| CHEMBL520022 | — | IC50 | - | — | - | |
| CHEMBL485596 | — | IC50 | - | — | - | |
| CHEMBL458749 | — | IC50 | - | — | - | |
| CHEMBL485226 | — | IC50 | - | — | - |