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Assay Detail

CHEMBL982826

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in bovine hippocampi synaptosomal membrane by liquid scintillation spectrometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Hippocampus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors.
Andrić D, Roglić G, Sukalović V, Soskić V, Kostić-Rajacić S.
Eur J Med Chem (2008) 43 : 1696 -1705
PubMed 18006194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.53 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488977 1 9.85
CHEMBL445347 1 8.85
CHEMBL510055 1 8.28
CHEMBL491233 1 7.69
CHEMBL485298 1 7.68
CHEMBL485499 1 7.62
CHEMBL521581 1 7.48
CHEMBL483247 1 7.34
CHEMBL483864 1 7.05
CHEMBL492042 1 7.05
CHEMBL488555 1 6.89
CHEMBL491232 1 6.71
CHEMBL489599 1 6.61
CHEMBL520019 1 6.28
CHEMBL522639 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488977 Ki = 0.14 nM 9.85
CHEMBL445347 Ki = 1.4 nM 8.85
CHEMBL510055 Ki = 5.2 nM 8.28
CHEMBL491233 Ki = 20.3 nM 7.69
CHEMBL485298 Ki = 20.7 nM 7.68
CHEMBL485499 Ki = 24.1 nM 7.62
CHEMBL521581 Ki = 33.0 nM 7.48
CHEMBL483247 Ki = 45.6 nM 7.34
CHEMBL483864 Ki = 89.6 nM 7.05
CHEMBL492042 Ki = 89.6 nM 7.05
CHEMBL488555 Ki = 129.0 nM 6.89
CHEMBL491232 Ki = 197.0 nM 6.71
CHEMBL489599 Ki = 243.0 nM 6.61
CHEMBL520019 Ki = 529.6 nM 6.28
CHEMBL522639 Ki > 1000.0 nM -