Assay Detail
Functional
CHEMBL982880
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Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 as LDH activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-N-Methyl modifications and SAR studies of manzamine A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.50 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.20 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.89 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 7.77 |
| CHEMBL443420 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL443420 | — | IC50 | = | 736.0 | nM | 6.13 |