Assay Detail
Functional
CHEMBL982890
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Antimicrobial activity against Cryptococcus neoformans ATCC 90113
10
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cryptococcus neoformans |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-N-Methyl modifications and SAR studies of manzamine A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.67 | 5.57 |
| MIC | 3 | - | - |
| MFC | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403233 | MANZAMINE A | — | 3 | 5.57 |
| CHEMBL454986 | — | — | 3 | 4.28 |
| CHEMBL443420 | — | — | 1 | 4.15 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403233 | MANZAMINE A | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL454986 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL443420 | — | IC50 | = | 71100.0 | nM | 4.15 |
| CHEMBL403233 | MANZAMINE A | MIC | = | 5700.0 | nM | - |
| CHEMBL403233 | MANZAMINE A | MFC | = | 23.0 | uM | - |
| CHEMBL454986 | — | MIC | = | 87000.0 | nM | - |
| CHEMBL454986 | — | MFC | = | 87.0 | uM | - |
| CHEMBL8 | CIPROFLOXACIN | IC50 | - | — | - | |
| CHEMBL8 | CIPROFLOXACIN | MIC | - | — | - | |
| CHEMBL8 | CIPROFLOXACIN | MFC | - | — | - |