Assay Detail
Binding
CHEMBL982904
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Inhibition of HIV1 recombinant protease D30N/N88D mutant expressed in Escherichia coli by spectrophotometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.69 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.96 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 10.59 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 10.26 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 9.89 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.29 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.06 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL729 | LOPINAVIR | Ki | = | 0.026 | nM | 10.59 |
| CHEMBL1163 | ATAZANAVIR | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL584 | NELFINAVIR | Ki | = | 18.0 | nM | 7.75 |