Assay Detail
Binding
CHEMBL982908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/A71V/G73S/L90M mutant expressed in Escherichia coli by spectrophotometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.41 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.82 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 10.54 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 10.12 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 9.82 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.68 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.54 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL729 | LOPINAVIR | Ki | = | 0.029 | nM | 10.54 |
| CHEMBL1163 | ATAZANAVIR | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL584 | NELFINAVIR | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 47.0 | nM | 7.33 |