Assay Detail
Binding
CHEMBL982936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NMDA NR1/NR2B receptor expressed in xenopus oocytes assessed as inhibition of NMDA and glycine-induced current response by two-electrode voltage clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.06 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478666 | CARBACRINE | — | 1 | 6.13 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.02 |
| CHEMBL474268 | — | — | 1 | 4.89 |
| CHEMBL473866 | — | — | 1 | 4.74 |
| CHEMBL478667 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478666 | CARBACRINE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL807 | MEMANTINE | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL474268 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL473866 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL478667 | — | IC50 | = | 30300.0 | nM | 4.52 |