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Assay Detail

CHEMBL983466

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Functional
Antiproliferative activity against mouse FM3A cells after 2 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type FM3A
Confidence 1 — Organism
Curated By Autocuration

Target

FM3A (CHEMBL614297)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Romagnoli R, Baraldi PG, Sarkar T, Carrion MD, Cruz-Lopez O, Lopez Cara C, Tolomeo M, Grimaudo S, Di Cristina A, Pipitone MR, Balzarini J, Gambari R, Ilaria L, Saletti R, Brancale A, Hamel E.
Bioorg Med Chem (2008) 16 : 8419 -8426
PubMed 18755591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.36 7.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.38
CHEMBL227987 1 7.34
CHEMBL492212 1 7.23
CHEMBL271388 1 7.01
CHEMBL489153 1 7.00
CHEMBL490384 1 6.58
CHEMBL522420 1 6.55
CHEMBL490180 1 6.25
CHEMBL491395 1 5.96
CHEMBL492213 1 5.92
CHEMBL523145 1 5.92
CHEMBL271171 1 5.80
CHEMBL490615 1 5.10
CHEMBL491397 1 5.06
CHEMBL364280 1 -
CHEMBL491598 1 -
CHEMBL523979 1 -
CHEMBL490616 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67 COMBRETASTATIN A4 IC50 = 42.0 nM 7.38
CHEMBL227987 IC50 = 46.0 nM 7.34
CHEMBL492212 IC50 = 59.0 nM 7.23
CHEMBL271388 IC50 = 97.0 nM 7.01
CHEMBL489153 IC50 = 100.0 nM 7.00
CHEMBL490384 IC50 = 260.0 nM 6.58
CHEMBL522420 IC50 = 280.0 nM 6.55
CHEMBL490180 IC50 = 560.0 nM 6.25
CHEMBL491395 IC50 = 1100.0 nM 5.96
CHEMBL492213 IC50 = 1200.0 nM 5.92
CHEMBL523145 IC50 = 1200.0 nM 5.92
CHEMBL271171 IC50 = 1600.0 nM 5.80
CHEMBL490615 IC50 = 7900.0 nM 5.10
CHEMBL491397 IC50 = 8800.0 nM 5.06
CHEMBL364280 IC50 > 10000.0 nM -
CHEMBL491598 IC50 > 10000.0 nM -
CHEMBL523979 IC50 > 10000.0 nM -
CHEMBL490616 IC50 > 10000.0 nM -