Assay Detail
Functional
CHEMBL983475
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Cytotoxicity against human K-562 after 24 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.86 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492212 | — | — | 1 | 7.17 |
| CHEMBL489153 | — | — | 1 | 7.07 |
| CHEMBL490384 | — | — | 1 | 6.94 |
| CHEMBL522420 | — | — | 1 | 6.92 |
| CHEMBL490180 | — | — | 1 | 6.67 |
| CHEMBL491395 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492212 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL489153 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL490384 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL522420 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL490180 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL491395 | — | IC50 | = | 400.0 | nM | 6.40 |