Assay Detail
Binding
CHEMBL983496
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Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.01 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522649 | — | — | 1 | 7.62 |
| CHEMBL491002 | — | — | 1 | 7.47 |
| CHEMBL491003 | — | — | 1 | 7.26 |
| CHEMBL492220 | — | — | 1 | 7.06 |
| CHEMBL573 | NIACIN | 4.0 | 1 | 6.89 |
| CHEMBL235740 | — | — | 1 | 6.85 |
| CHEMBL443733 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522649 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL491002 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL491003 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL492220 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL573 | NIACIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL235740 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL443733 | — | IC50 | = | 1200.0 | nM | 5.92 |