Assay Detail
Functional
CHEMBL983499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.91 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522649 | — | — | 1 | 6.42 |
| CHEMBL491002 | — | — | 1 | 6.27 |
| CHEMBL491003 | — | — | 1 | 6.03 |
| CHEMBL235740 | — | — | 1 | 6.00 |
| CHEMBL443733 | — | — | 1 | 5.92 |
| CHEMBL573 | NIACIN | 4.0 | 1 | 5.85 |
| CHEMBL228244 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522649 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL491002 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL491003 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL235740 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL443733 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL573 | NIACIN | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL228244 | — | EC50 | = | 12500.0 | nM | 4.90 |