Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL983516

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]flunitrazepam from central benzodiazepine receptor in Sprague-Dawley rat cerebral cortex membrane by liquid scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Cerebral cortex
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies.
Denora N, Laquintana V, Pisu MG, Dore R, Murru L, Latrofa A, Trapani G, Sanna E.
J Med Chem (2008) 51 : 6876 -6888
PubMed 18834105 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 6.06 6.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520847 1 6.71
CHEMBL484188 1 6.61
CHEMBL483383 1 6.27
CHEMBL485606 1 6.00
CHEMBL520652 1 5.99
CHEMBL484574 1 5.53
CHEMBL484741 1 5.29
CHEMBL509917 1 -
CHEMBL521186 1 -
CHEMBL484932 1 -
CHEMBL483172 1 -
CHEMBL520465 1 -
CHEMBL485217 1 -
CHEMBL485218 1 -
CHEMBL485219 1 -
CHEMBL519654 1 -
CHEMBL481537 PK-11195 1 -
CHEMBL485589 1 -
CHEMBL520662 1 -
CHEMBL484750 1 -
CHEMBL484758 1 -
CHEMBL484573 1 -
CHEMBL521304 1 -
CHEMBL485435 1 -
CHEMBL483596 1 -
CHEMBL220661 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520847 Ki = 194.0 nM 6.71
CHEMBL484188 Ki = 246.0 nM 6.61
CHEMBL483383 Ki = 535.0 nM 6.27
CHEMBL485606 Ki = 1000.0 nM 6.00
CHEMBL520652 Ki = 1024.0 nM 5.99
CHEMBL484574 Ki = 2930.0 nM 5.53
CHEMBL484741 Ki = 5130.0 nM 5.29
CHEMBL509917 Ki > 10.0 nM -
CHEMBL521186 Ki > 10.0 nM -
CHEMBL484932 Ki > 10.0 nM -
CHEMBL483172 Ki > 10.0 nM -
CHEMBL520465 Ki > 10.0 nM -
CHEMBL485217 Ki > 10.0 nM -
CHEMBL485218 Ki > 10.0 nM -
CHEMBL485219 Ki > 10.0 nM -
CHEMBL519654 Ki > 10.0 nM -
CHEMBL481537 PK-11195 Ki > 10.0 nM -
CHEMBL485589 Ki > 10.0 nM -
CHEMBL520662 Ki > 10.0 nM -
CHEMBL484750 Ki > 10.0 nM -
CHEMBL484758 Ki > 10.0 nM -
CHEMBL484573 Ki > 10.0 nM -
CHEMBL521304 Ki > 10.0 nM -
CHEMBL485435 Ki > 10.0 nM -
CHEMBL483596 Ki > 10.0 nM -
CHEMBL220661 Ki > 10.0 nM -