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Assay Detail

CHEMBL983573

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Functional
Antiproliferative activity against human MCF7 cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents.
Bavikar SN, Salunke DB, Hazra BG, Pore VS, Dodd RH, Thierry J, Shirazi F, Deshpande MV, Kadreppa S, Chattopadhyay S.
Bioorg Med Chem Lett (2008) 18 : 5512 -5517
PubMed 18805690 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.15 4.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL205596 CHOLIC ACID 4.0 1 4.30
CHEMBL500877 1 4.00
CHEMBL443511 1 -
CHEMBL1162373 1 -
CHEMBL1162374 1 -
CHEMBL3138441 1 -
CHEMBL444443 1 -
CHEMBL502442 1 -
CHEMBL3138459 1 -
CHEMBL1162375 1 -
CHEMBL504113 1 -
CHEMBL1162376 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL205596 CHOLIC ACID IC50 = 50000.0 nM 4.30
CHEMBL500877 IC50 = 100000.0 nM 4.00
CHEMBL443511 IC50 = 300000.0 nM -
CHEMBL1162373 IC50 = 500000.0 nM -
CHEMBL1162374 IC50 = 600000.0 nM -
CHEMBL3138441 IC50 > 1000000.0 nM -
CHEMBL444443 IC50 = 200000.0 nM -
CHEMBL502442 IC50 = 500000.0 nM -
CHEMBL3138459 IC50 = 150000.0 nM -
CHEMBL1162375 IC50 = 150000.0 nM -
CHEMBL504113 IC50 > 1000000.0 nM -
CHEMBL1162376 IC50 > 1000000.0 nM -