Assay Detail
Binding
CHEMBL983683
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Antagonist activity at mineralocorticoid receptor by Gal4-DNA binding domain-hormone receptor LBD one-hybrid assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.12 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489788 | — | — | 1 | 6.81 |
| CHEMBL522432 | — | — | 1 | 6.36 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 6.23 |
| CHEMBL520169 | — | — | 1 | 5.64 |
| CHEMBL483246 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489788 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL522432 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL520169 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL483246 | — | IC50 | = | 2800.0 | nM | 5.55 |